Perfluoropentanone (C

5

F

10

O)

as an environmentally friendly gas insulating medium

has the potential to replace SF

6

in medium and low voltage gas insulating equipment

. However

there are fewer studies related to the biosafety of C

5

F

10

O

especially its bioteratogenic effects. In order to ensure the safety of C

5

F

10

O in the power industry

it is necessary to carry out more comprehensive toxicological studies on C

5

F

10

O gas. In this paper

we conducted an inhalation study of C

5

F

10

O gas on pregnant rats during the embryonic organogenesis stage

and then examined and analysed the vital signs of pregnant rats and foetuses as well as the development of foetuses in order to systematically assess the potential of teratogenicity of the offspring caused by inhalation of a certain concentration of C

5

F

10

O gas. The experimental results showed that the inhalation of high concentration of C

5

F

10

O gas may lead to the presence of visceral malformations

skeletal underdevelopment and other undesirable phenomena in the offspring of rats

but did not show obvious statistical significance

and the maximum no-acting teratogenic dose (NOAEL) observed in the teratogenicity test on rats was 7 715.3 μL/L

and the relevant results can provide important references for the engineering application and safety protection strategy of C

5

F

10

O. The relevant results can provide an important

reference for the engineering application and safety protection strategy of C

5

F

10

O.